Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …

Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …

Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …

Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is
a key tumour suppression mechanism,,–. Glutathione peroxidase 4 (GPX4), and ferroptosis …

Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited
in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic …