Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Traumatic, tumoral, and infectious bone defects are common in clinics, and create a big
burden on patient's families and society. Calcium phosphate (CaP)-based biomaterials have …

Proper immune responses are critical for successful biomaterial implantation. Here, four
scales of honeycomb-like TiO2 structures were custom made on titanium (Ti) substrates to …

Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

The immune microenvironment induced by biomaterials played vital roles in bone
regeneration. Hydroxyapatite (HA) and its ion-substituted derivates represent a large class …

Tissue repair after trauma and infection has always been a difficult problem in regenerative
medicine. Hydrogels have become one of the most important scaffolds for tissue …

Bone resorption can negatively influence the osseointegration of dental implants. Barrier
membranes for guided bone regeneration (GBR) are used to exclude nonosteogenic tissues …

A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …

Precise timing of macrophage polarization plays a pivotal role in immunomodulation of
tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti …