Gut-immunity-joint axis: a new therapeutic target for gouty arthritis

P Chen, Z Luo, C Lu, G Jian, X Qi… - Frontiers in Pharmacology, 2024 - frontiersin.org
Gouty arthritis (GA) is an inflammatory disease characterized by pain. The primary goal of
current treatment strategies during GA flares remains the reduction of inflammation and pain …

[HTML][HTML] Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response

M Kumar, S Sharma, J Kumar, S Barik… - Current Research in …, 2024 - Elsevier
Macrophages restrain microbial infection and reinstate tissue homeostasis. The
mitochondria govern macrophage metabolism and serve as pivot in innate immunity, thus …

Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway

T Wang, L Yu, J Zheng, X Han, B Jin, C Hua… - Chinese Journal of …, 2024 - Springer
Methods Eight 8-week-old C57BL/6J mice were used as a blank control group (normal), and
56 8-week-old AopE−/− mice were fed a high-fat diet for 12 weeks, according to a …

Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice

RN Zhou, ZW Zhu, PY Xu, LX Shen, Z Wang… - Communications …, 2024 - nature.com
Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory
properties. Here, we show that rhein mitigates obesity by promoting adipose tissue …

A neolignan enantiomer from Piper hancei with anti-neuroinflammatory effect by attenuating NF-κB signaling pathway

Q Lan, S He, JL Liu, Y Wang, D Liang - Phytomedicine, 2024 - Elsevier
ABSTRACT Background In the traditional “Yao” ethno-medicine system, Piper hancei
Maxim. is used to treat rheumatism, wind-cold, and inflammation. Previous studies indicate …

Acetylation model predicts prognosis of patients and affects immune microenvironment infiltration in epithelial ovarian carcinoma

X Wang, X Li, L Wei, Y Yu, Y Hazaisihan, L Tao… - Journal of Ovarian …, 2024 - Springer
Background Epithelial ovarian carcinoma (EOC) is a prevalent gynaecological malignancy.
The prognosis of patients with EOC is related to acetylation modifications and immune …

[HTML][HTML] Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration

J Sun, Q Zeng, Z Wu, L Huang, T Sun, C Ling, B Zhang… - …, 2024 - Elsevier
Berberine (BBR) has demonstrated potent anti-inflammatory effects by modulating
macrophage polarization. Nevertheless, the precise mechanisms through which berberine …

Huanglian-Jiedu decoction promotes adipose thermogenesis in obese mice by suppressing the expression of HDAC3

P Xu, Z Zhu, R Zhou, Y Wei, F Xu, L Shen… - Journal of …, 2025 - Elsevier
Abstract Ethnopharmacological relevance Huanglian Jiedu Decoction (HLJDD) is an
ancient formula of traditional Chinese medicine that is commonly utilized in a range of …

Bioinformatic analysis of hippocampal histopathology in Alzheimer's disease and the therapeutic effects of active components of traditional Chinese medicine

C Zhiyan, Z Min, D Yida, H Chunying… - Frontiers in …, 2024 - frontiersin.org
Background and aim Pathological changes in the central nervous system (CNS) begin
before the clinical symptoms of Alzheimer's Disease (AD) manifest, with the hippocampus …

[PDF][PDF] Qingre Jiangni formula improves esophageal epithelial barrier function in gastroesophageal reflux rats through male hormones and the p38/MAPK pathway

Z Jiang, D Lu, Z Sun, W Wen - Journal of Men's Health, 2024 - oss.jomh.org
The incidence rate of gastroesophageal reflux is high. Qingre Jiangni Formula has shown
good clinical efficacy. In this study, the therapeutic effect of this formula on inflammation was …