Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Cholinergic system during the progression of Alzheimer's disease: therapeutic implications

EJ Mufson, SE Counts, SE Perez… - Expert review of …, 2008 - Taylor & Francis
Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

[图书][B] What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice

JN Crawley - 2007 - books.google.com
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

Hippocampal plasticity during the progression of Alzheimer's disease

EJ Mufson, L Mahady, D Waters, SE Counts, SE Perez… - Neuroscience, 2015 - Elsevier
Neuroplasticity involves molecular and structural changes in central nervous system (CNS)
throughout life. The concept of neural organization allows for remodeling as a compensatory …

Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease

BA Kent, HH Feldman, HB Nygaard - Progress in neurobiology, 2021 - Elsevier
A majority of patients with Alzheimer's disease (AD) experience some form of sleep
disruption, including nocturnal sleep fragmentation, increased daytime napping, decreased …

Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors

W Froestl, A Muhs, A Pfeifer - Journal of Alzheimer's disease, 2012 - content.iospress.com
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Cholinotrophic molecular substrates of mild cognitive impairment in the elderly

EJ Mufson, SE Counts, M Fahnestock… - Current Alzheimer …, 2007 - ingentaconnect.com
Cholinergic nucleus basalis (NB) neurons provide the major cholinergic innervation to the
cortical mantle, are selectively vulnerable in late stage Alzheimer's disease (AD) and require …

Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze

KR Bailey, MN Pavlova, AD Rohde… - Pharmacology …, 2007 - Elsevier
The neuropeptide galanin has been implicated in anxiety-related behaviors, cognition,
analgesia, and feeding in rodents. Neuromodulatory actions of galanin are mediated by …

Galanin and its receptors in neurological disorders

L Lundström, A Elmquist, T Bartfai, Ü Langel - Neuromolecular medicine, 2005 - Springer
Galanin is a highly inducible neuropeptide, showing distinct up-regulation after pathological
disturbance within the nervous system. Significant increase in galanin expression is …

Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells

G Tang, Y Wang, S Park… - Proceedings of the …, 2012 - National Acad Sciences
The neuropeptide galanin regulates numerous physiological activities in the body, including
feeding and metabolism, learning and memory, nociception and spinal reflexes, and anxiety …