The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
[HTML][HTML] Metabolism, metabolites, and macrophages in cancer
M Li, Y Yang, L Xiong, P Jiang, J Wang, C Li - Journal of hematology & …, 2023 - Springer
Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …
microenvironment and play a significant role in tumour development and drug resistance by …
[HTML][HTML] m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
[HTML][HTML] Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application
F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …
[HTML][HTML] Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents
M Hashemi, MSA Mirdamadi, Y Talebi… - Pharmacological …, 2023 - Elsevier
The field of non-coding RNA (ncRNA) has made significant progress in understanding the
pathogenesis of diseases and has broadened our knowledge towards their targeting …
pathogenesis of diseases and has broadened our knowledge towards their targeting …
[HTML][HTML] The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer
CY Sun, D Cao, BB Du, CW Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …
[HTML][HTML] Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
TY Zhu, LL Hong, ZQ Ling - Biomarker research, 2023 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic …
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic …
[HTML][HTML] m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
SW Yue, HL Liu, HF Su, C Luo, HF Liang, BX Zhang… - Molecular Cancer, 2023 - Springer
Glycolytic reprogramming is one of the most important features of cancer and plays an
integral role in the progression of cancer. In cancer cells, changes in glucose metabolism …
integral role in the progression of cancer. In cancer cells, changes in glucose metabolism …
[HTML][HTML] LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on …
F Wang, Y Hu, H Wang, P Hu, H Xiong, Z Zeng… - Journal of Experimental …, 2023 - Springer
Abstract Background Long non-coding RNAs (LncRNAs) have been extensively studied to
play essential roles in tumor progression. However, more in-depth studies are waiting to be …
play essential roles in tumor progression. However, more in-depth studies are waiting to be …
[HTML][HTML] Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors
H Zhou, Q Sun, M Feng, Z Gao, S Jia, L Cao, X Yu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological
functions as post-transcriptional performers, participating in the acquisition or maintenance …
functions as post-transcriptional performers, participating in the acquisition or maintenance …