Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular
receptor for protein C on endothelial cells. EPCR plays a crucial role in the protein C …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

The elusive task of defining the character of γδ T cells has been an evolving process for
immunologists since stumbling upon their existence during the molecular characterization of …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Protease‐activated receptors (PARs) are a family of highly conserved G protein‐coupled
receptors (GPCRs) that respond to extracellular proteases via a unique proteolysis …

Focal changes in the presence of a systemic prothrombotic state are evident in diseases of
veins, arteries, and microvessels. There seems to be a dual basis for this focality, residing in …

Th17 cells are key players in defense against pathogens and maintaining tissue
homeostasis, but also act as critical drivers of autoimmune diseases. Based on single-cell …

Endothelial cell protein C receptor-dependent signaling : Current Opinion in Hematology
Endothelial cell protein C receptor-dependent signaling : Current Opinion in Hematology Log …

Endothelial protein C receptor (EPCR) and protease activated receptor 1 (PAR-1) by
themselves play important role in cancer growth and dissemination. Moreover, interactions …

Hemophilia A and B are hereditary coagulation defects resulting in unstable blood clotting
and recurrent bleeding. Current factor replacement therapies have major limitations such as …