Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this
decline can become a major impediment to normal daily life. Recent research shows that the …

Clinical and experimental evidence point to a possible role of cerebrovascular dysfunction in
Alzheimer's disease (AD). The 5xFAD mouse model of AD expresses human amyloid …

Apolipoprotein (APOE) e4 genotype is an accepted risk factor for accelerated cognitive
aging and dementia, though its neurostructural substrates are unclear. The deleterious …

Introduction Emerging evidence has suggested that cerebral small vessel disease (CSVD)
may worsen motor function and cognition in Parkinson's disease (PD). However, the effect of …

Aging is one of the main risk factors for cognitive dysfunction. During aging process, the
decrease of brain-derived neurotrophic factor (BDNF) and the impairment of astrocyte …

Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for
developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and …

Abstract Purpose of Review Precision Aging® is a novel concept that we have recently
employed to describe how the model of precision medicine can be used to understand and …

Alzheimer's disease, characterized by brain deposits of amyloid-β plaques and
neurofibrillary tangles, is also linked to neurovascular dysfunction and blood–brain barrier …

Alzheimer's disease (AD) is a devastating neurological degenerative disorder and is the
most common cause of dementia in the elderly. Clinically, AD manifests with memory and …