Introduction This study assessed the associations of multimorbidity burden and its
developmental trajectory with later‐life dementia. Methods Among 5923 Health and …

Background: To study the extent to which neuropsychiatric symptoms (NPS) influence the
cognitive and functional decline in frontotemporal degeneration (FTD) and Alzheimer's …

The current “one size fits all” approach to our cognitive aging population is not adequate to
close the gap between cognitive health span and lifespan. In this review article, we present …

The microvasculature is a heterogeneous, dynamic and versatile component of the systemic
circulation, with a unique ability to locally self‐regulate and to respond to organ demand and …

New roles of the Renin-Angiotensin System (RAS), apart from fluid homeostasis and Blood
Pressure (BP) regulation, are being progressively unveiled, since the discoveries of RAS …

Endothelial cells drive the formation of new blood vessels in physiological and pathological
contexts such as embryonic development, wound healing, cancer and ocular diseases …

Abstract Purpose of Review Amyloid beta (Aβ) plaque accumulation is a hallmark pathology
contributing to Alzheimer's disease (AD) and is widely hypothesized to lead to cognitive …

The cerebral vasculature provides blood flow throughout the brain, and local changes in
blood flow are regulated to match the metabolic demands of the active brain regions. This …

Endothelial cells are the main component of the blood-brain barrier (BBB), a vital structure
for maintaining brain homeostasis that is seriously disrupted in various neurological …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by
Amyloid-β accumulation-induced neuronal injury. Emerging evidence shows that circular …