Common variant in PTK2B is associated with late-onset Alzheimer's disease: a replication study and meta-analyses
YQ Li, MS Tan, HF Wang, CC Tan, W Zhang… - Neuroscience …, 2016 - Elsevier
Emerging evidence indicates that protein tyrosine kinase 2β (PTK2B) is involved in the
pathogenesis of Alzheimer's disease (AD). Recently, a large, two-stage meta-analysis of …
pathogenesis of Alzheimer's disease (AD). Recently, a large, two-stage meta-analysis of …
The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases
J Chen, Y Pan, Q Liu, G Li, G Chen, W Li… - Current …, 2024 - ingentaconnect.com
Meningeal lymphatic vessels (MLVs) are essential for the drainage of cerebrospinal fluid,
macromolecules, and immune cells in the central nervous system. They play critical roles in …
macromolecules, and immune cells in the central nervous system. They play critical roles in …
[HTML][HTML] Pathologic sequelae of vascular cognitive impairment and dementia sheds light on potential targets for intervention
AE Linton, EM Weekman, DM Wilcock - Cerebral Circulation-Cognition and …, 2021 - Elsevier
Vascular contributions to cognitive impairment and dementia (VCID) is one of the leading
causes of dementia along with Alzheimer's disease (AD) and, importantly, VCID often …
causes of dementia along with Alzheimer's disease (AD) and, importantly, VCID often …
[HTML][HTML] A computational study of fluid transport characteristics in the brain parenchyma of dementia subtypes
The cerebral environment is a complex system consisting of parenchymal tissue and
multiple fluids. Dementia is a common class of neurodegenerative diseases, caused by …
multiple fluids. Dementia is a common class of neurodegenerative diseases, caused by …
Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance
OM Dumitrascu, J Doustar, DT Fuchs, Y Koronyo… - bioRxiv, 2024 - biorxiv.org
Introduction: The vascular contribution to Alzheimer's disease (AD) is tightly connected to
cognitive performance across the AD continuum. We topographically describe retinal …
cognitive performance across the AD continuum. We topographically describe retinal …
Chronic hippocampal expression of notch intracellular domain induces vascular thickening, reduces glucose availability, and exacerbates spatial memory deficits in a …
P Galeano, MC Leal, CC Ferrari, MC Dalmasso… - Molecular …, 2018 - Springer
The specific roles of Notch in progressive adulthood neurodegenerative disorders have
begun to be unraveled in recent years. A number of independent studies have shown …
begun to be unraveled in recent years. A number of independent studies have shown …
Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia
Background Cerebral small vessel disease is a progressive disease of the brain's deep
perforating blood vessels. It is usually diagnosed based on lesions seen on brain imaging …
perforating blood vessels. It is usually diagnosed based on lesions seen on brain imaging …
Expert System Detect Stroke with Dempster Shafer Method
One of the many diseases experienced by Indonesians is stroke. Stroke is a condition that
occurs when blood supply to the brain is cut off due to blockage or rupture of blood vessels …
occurs when blood supply to the brain is cut off due to blockage or rupture of blood vessels …
Donepezil improves vascular function in a mouse model of Alzheimer's disease
C Pellegrini, V D'Antongiovanni… - Pharmacology …, 2021 - Wiley Online Library
Cardiovascular complications in Alzheimer's disease (AD) patients can occur years to
decades prior to the onset of clinical symptoms of the disease. Donepezil represents the …
decades prior to the onset of clinical symptoms of the disease. Donepezil represents the …
Neurobiological Mechanisms of Cognitive Decline Correlated with Brain Aging
X Zhang, H An, Y Chen, N Shu - Cognitive Aging and Brain Health, 2023 - Springer
Cognitive decline has emerged as one of the greatest health threats of old age. Meanwhile,
aging is the primary risk factor for Alzheimer's disease (AD) and other prevalent …
aging is the primary risk factor for Alzheimer's disease (AD) and other prevalent …