Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Dendrites and spines are the main neuronal structures receiving input from other neurons
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

Activity-dependent plasticity of synaptic structure and function plays an essential role in
neuronal development and in cognitive functions including learning and memory. The …

Abstract A strong genetic predisposition (60–80% of attributable risk) is present in
Alzheimer's disease (AD). In view of this major genetic component, identification of the …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

Although the genetic causes for several rare, familial forms of Alzheimer's disease (AD) have
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …

Altered abundance or activity of the dual-function transient receptor potential melastatin-like
7 (TRPM7) protein is implicated in neurodegenerative disorders, including Alzheimer's …

Dendritic spine loss is recognized as an early feature of Alzheimer's disease (AD), but the
underlying mechanisms are poorly understood. Dendritic spine structure is defined by …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by Aβ-driven
synaptic dysfunction in the early phases of pathogenesis. In the synaptic context, the actin …