The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Despite progress in understanding the pathophysiology of acute lung damage, currently
approved treatment possibilities are limited to lung-protective ventilation, prone positioning …

Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in
premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal …

Background While additional oxygen supply is often required for the survival of very
premature infants in intensive care, this also brings an increasing risk of progressive lung …

Apnea of prematurity (AOP) is a common and pervasive problem in very low birth weight
infants. Methylxanthines were reported> 40 years ago to be an effective therapy and, by the …

Abstract Objective GTP cyclohydrolase 1 (GCH1) was reported to protect against ferroptosis.
However, it is not clear whether GCH1 reduced lipopolysaccharide (LPS)-induced …

Background Caffeine therapy for apnea of prematurity reduces the incidence of
bronchopulmonary dysplasia (BPD) in premature neonates. Several mechanisms, including …

Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease that occurs during the
neonatal period and is commonly associated with prematurity. This condition results in a …

Genotoxic therapy triggers reactive oxygen species (ROS) production and oxidative tissue
injury. S-nitrosylation is a selective and reversible posttranslational modification of protein …

During the progression of acute lung injury (ALI), oxidative stress and inflammatory
responses always promote each other. The datasets analyzed in this research were …