In liver and intestine, transporters play a critical role in maintaining the enterohepatic
circulation and bile acid homeostasis. Over the past two decades, there has been significant …

Sulfotransferase-2A1 catalyzes the formation of bile acid-sulfates (BA-sulfates). Sulfation of
BAs increases their solubility, decreases their intestinal absorption, and enhances their fecal …

Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively
important organic components of bile, where they are the main driving force of the osmotic …

Membrane transporters expressed by the hepatocyte and enterocyte play critical roles in
maintaining the enterohepatic circulation of bile acids, an effective recycling and …

Quantitative gas chromatography‐mass spectrometry was used to study the metabolic
profiles of unconjugated, conjugated and sulphated bile acids in urine of patients with …

Oral vitamin D 3 was poorly absorbed by 4 out of 6 patients with primary biliary cirrhosis;
absorption was negatively correlated with fæcal fat excretion. 25-hydroxylation of vitamin D …

We have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in
seven patients with moderate to severe primary biliary cirrhosis. Bile acids were …

The metabolism of 14C-labeled chenodeoxycholic, cholic, and deoxycholic acids was
studied in patients with intrahepatic cholestasis. Radioactively labeled metabolites were …

Abstract Studies of 14 North American Indian children with a familial type of severe neonatal
cholestasis are described. Jaundice occurred during the neonatal period in 9 children, but …

In patients with hepatobiliary diseases, considerable amounts of sulfated and
glucuronidated bile acids are excreted in urine. Information on the biliary excretion of these …