Anti-cancer drug molecules targeting cancer cell cycle and proliferation
Cancer, a vicious clinical burden that potentiates maximum fatality for humankind, arises
due to unregulated excessive cell division and proliferation through an eccentric expression …
due to unregulated excessive cell division and proliferation through an eccentric expression …
Luteoloside induces apoptosis in human HCT116 colorectal cancer cells via mitochondrial and PI3K/AKT signaling pathways
J Zhang, XX Zhang, WW Zhang, K Thakur, JG Zhang… - Food Bioscience, 2024 - Elsevier
Luteoloside (LUS), a flavonoid isolated from the flower stem leaves of honeysuckle, exhibits
anticancer activity. Nevertheless, further comprehensive and articulate research is still …
anticancer activity. Nevertheless, further comprehensive and articulate research is still …
Cyclin-dependent kinase inhibitors for the treatment of lung cancer
A Qin, HG Reddy, FD Weinberg… - Expert Opinion on …, 2020 - Taylor & Francis
ABSTRACT Introduction Cyclin-dependent kinases (CDKs) are critical regulators of cell
cycle progression in both normal and malignant cells, functioning through complex …
cycle progression in both normal and malignant cells, functioning through complex …
Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight
Rosavin is an alkylbenzene diglycoside primarily found in Rhodiola rosea (L.),
demonstrating various pharmacological properties in a number of preclinical test systems …
demonstrating various pharmacological properties in a number of preclinical test systems …
Putting the brakes on tumorigenesis with natural products of plant origin: insights into the molecular mechanisms of actions and immune targets for bladder cancer …
Bladder cancer is the 10th most commonly diagnosed cancer worldwide. Although the
incidence in men is 4 times higher than that in women, the diagnoses are worse for women …
incidence in men is 4 times higher than that in women, the diagnoses are worse for women …
Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines
A series of thirteen new aryl/hetarylbichalcophene-5-carboxamidines was prepared and
screened for an in vitro anti-proliferative activity against sixty cancer cell lines. The tested …
screened for an in vitro anti-proliferative activity against sixty cancer cell lines. The tested …
Effect of cell adhesiveness of Cell Dome shell on enclosed HeLa cells
The Cell Dome is a dome-shaped structure (diameter: 1 mm, height: 270 μm) with cells
enclosed within a cavity, covered by a hemispherical hydrogel shell, and immobilized on a …
enclosed within a cavity, covered by a hemispherical hydrogel shell, and immobilized on a …
The proliferative and apoptotic landscape of basal-like breast cancer
Basal-like breast cancer (BLBC) is an aggressive molecular subtype that represents up to
15% of breast cancers. It occurs in younger patients, and typically shows rapid development …
15% of breast cancers. It occurs in younger patients, and typically shows rapid development …
Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells.
YH Choi - General Physiology & Biophysics, 2019 - search.ebscohost.com
Abstract Isorhamnetin is a 3'-O-methylated metabolite of quercetin that is found
predominantly in a variety of medicinal plants. Although many previous studies have …
predominantly in a variety of medicinal plants. Although many previous studies have …
Recent advances in the development of cyclin-dependent kinase 7 inhibitors
Y Teng, K Lu, Q Zhang, L Zhao, Y Huang… - European Journal of …, 2019 - Elsevier
Abstract Cyclin dependent kinase 7 (CDK7) plays a double role as it activates several other
cyclin dependent kinases and participates to the initiation of transcription. This kinase is …
cyclin dependent kinases and participates to the initiation of transcription. This kinase is …