Design, synthesis, structure-activity relationships and mechanism of action of new quinoline derivatives as potential antitumor agents

S Li, L Hu, J Li, J Zhu, F Zeng, Q Huang, L Qiu… - European Journal of …, 2019 - Elsevier
A series of new quinoline derivatives was designed, synthesized and evaluated as potential
antitumor agents. The results indicated that most compounds exhibited potent …

[HTML][HTML] ATM in breast and brain tumors: a comprehensive review

MA Estiar, P Mehdipour - Cancer biology & medicine, 2018 - ncbi.nlm.nih.gov
The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is
characterized by predisposition to cancer. Patients with AT have an elevated risk of breast …

Cytotoxic and proapoptotic effect of doxycycline–An in vitro study on the human skin melanoma cells

J Rok, M Karkoszka, Z Rzepka, M Respondek… - Toxicology in Vitro, 2020 - Elsevier
Doxycycline is a semisynthetic, second generation tetracycline. Currently, it is used, among
others, in the treatment of acne and skin infections. Moreover, doxycycline has many …

A novel drug delivery system: The encapsulation of naringenin in metal-organic frameworks into liposomes

Z Wang, L Liu, W Yin, Z Liu, L Shi, M Tang - AAPS PharmSciTech, 2021 - Springer
Poorly water-soluble naringenin (NAR) was selected as a model drug and loaded into the
porous MOFs for the construction of NAR@ ZIF-8 inclusion complex. By film dispersion …

Compound K: A systematic review of its anticancer properties and probable mechanisms

DNH Tam, NH Nam, NTK Cuong… - Fundamental & …, 2023 - Wiley Online Library
Panax ginseng is a common natural product, which is well‐known to have a wide range of
pharmacological activities in cancer. Its metabolite, compound K (CK), has been reported to …

Nanomedicine Advancements: Vanadium Oxide Nanoparticles as a Game-Changer in Antimicrobial and Anticancer Therapies

A Efunnuga, A Efunnuga, AP Onivefu, IH Ifijen, M Maliki… - BioNanoScience, 2024 - Springer
This review examines nanomedicine's dynamic landscape, emphasizing vanadium oxide
nanoparticles (V 2 O 5 NPs) and their pivotal role in antimicrobial and anticancer therapies …

Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to …

A Kumar, MA Alfhili, A Bari, H Ennaji… - Frontiers in Cell and …, 2022 - frontiersin.org
Due to poor diagnosis breast cancer in women has emerged as the most common cause of
death disease in developing countries. Medicinal plants have been used for thousands of …

[HTML][HTML] Podophyllotoxin induces ROS-mediated apoptosis and cell cycle arrest in human colorectal cancer cells via p38 MAPK signaling

SO Lee, SH Joo, AW Kwak, MH Lee… - Biomolecules & …, 2021 - ncbi.nlm.nih.gov
Podophyllotoxin (PT), a lignan compound from the roots and rhizomes of Podophyllum
peltatum, has diverse pharmacological activities including anticancer effect in several types …

[HTML][HTML] Cordycepin inhibits the proliferation of malignant peripheral nerve sheath tumor cells through the p53/Sp1/tubulin pathway

MJ Lee, JC Lee, JH Hsieh, MY Lin, IA Shih… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Abstract Neurofibromatosis type 1 (NF1) is one of the most common hereditary
neurocutaneous disorders. In addition to skin pigmentation and cutaneous neurofibroma …

Involvement of phytochemical-encapsulated nanoparticles' interaction with cellular signalling in the amelioration of benign and malignant brain tumours

S Mehan, N Arora, S Bhalla, A Khan, MU Rehman… - Molecules, 2022 - mdpi.com
Brain tumours have unresolved challenges that include delay prognosis and lower patient
survival rate. The increased understanding of the molecular pathways underlying cancer …