Successful treatment of hypertension is difficult despite the availability of several classes of
antihypertensive drug, and the value of strategies to combat the effect of adverse lifestyle …

Despite considerable therapeutic advances, heart failure remains a medical and
socioeconomic problem. Thus, there is a compelling need for new drugs that could improve …

Despite the existence of established, effective therapies for hypertension, new methods of
blood pressure and cardiovascular risk reduction are still needed. Novel approaches are …

The conventional antihypertensive therapies including renin–angiotensin–aldosterone
system antagonists (converting enzyme inhibitors, receptor blockers, renin inhibitors, and …

The prorenin receptor was originally discovered as a receptor that binds renin and prorenin,
thereby inducing pro-fibrotic intracellular signal cascades. These effects are partially …

Abstract The (pro) renin receptor ((P) RR) is not only a member of the renin-angiotensin
system (RAS) but also exerts several RAS-independent functions due to its multiple signal …

BACKGROUND: There is increasing evidence that renin–angiotensin system (RAS) may
play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS) …

The overactivation of the renin-angiotensin-aldosterone system accounts for many
cardiovascular and renal abnormalities. At several levels of its cascade, the renin …

Hypertension is the most common cardiovascular disease and remains the most prevalent
risk factor for cardiovascular diseases and a major cause of death worldwide. Despite the …

Cardiac hypertrophy is classically considered as an adaptive and compensatory response
enabling cardiomyocytes to increase their work output and thus cardiac function …