Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

The global epidemic of obesity is a major public health problem today. Obesity increases the
risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

In mammals, the neuroendocrine system, which includes the communication between the
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …

Aging is a natural process of organismal decay that underpins the development of myriad
diseases and disorders. Extensive efforts have been made to understand the biology of …

During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …

The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …