Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

[HTML][HTML] The emerging hallmarks of cancer metabolism

NN Pavlova, CB Thompson - Cell metabolism, 2016 - cell.com
Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Z Zhao, CB Swartchick, J Chan - Chemical Society Reviews, 2022 - pubs.rsc.org
Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution
visualization of biological processes within deep tissue. Through the development and …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

Stimuli‐responsive NO release for on‐demand gas‐sensitized synergistic cancer therapy

W Fan, BC Yung, X Chen - Angewandte Chemie International …, 2018 - Wiley Online Library
Featuring high biocompatibility, the emerging field of gas therapy has attracted extensive
attention in the medical and scientific communities. Currently, considerable research has …

Redox regulation and its emerging roles in cancer treatment

H Zhang, Z Mao, Y Kang, W Zhang, L Mei… - Coordination Chemistry …, 2023 - Elsevier
Intracellular reduction–oxidation (redox) homeostasis, mediated mainly by reactive oxygen
species (ROS), plays a significant role in physiological function maintenance and regulation …

[HTML][HTML] H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

L Wu, Y Ishigaki, Y Hu, K Sugimoto, W Zeng… - Nature …, 2020 - nature.com
Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo
imaging; however, such probes that can be selectively delivered into target sites and switch …

Zwitterion‐Based hydrogen sulfide nanomotors induce multiple acidosis in tumor cells by destroying tumor metabolic symbiosis

M Wan, Z Liu, T Li, H Chen, Q Wang… - Angewandte …, 2021 - Wiley Online Library
Destruction of tumor metabolism symbiosis is an attractive cancer treatment method which
targets tumor cells with little harm to normal cells. Yet, a single intervention strategy and poor …

[HTML][HTML] Hydrogen sulfide: from a toxic molecule to a key molecule of cell life

A Aroca, C Gotor, DC Bassham, LC Romero - Antioxidants, 2020 - mdpi.com
Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles
published more recently showed the beneficial biochemical properties of its endogenous …