Epidemiological and biological plausibility studies support a cause-and-effect relationship
between increased levels of physical activity or cardiorespiratory fitness and reduced …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Background: Automated cardiac image interpretation has the potential to transform clinical
practice in multiple ways, including enabling serial assessment of cardiac function by …

Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

In response to stress, the heart undergoes extensive cardiac remodeling that results in
cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute …

Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac
output during detrimental stimuli. Nevertheless, long-term stimuli incite chronic hypertrophy …

Background: Mitral valve prolapse (MVP) is a frequent disease that can be complicated by
mitral regurgitation (MR), heart failure, arterial embolism, rhythm disorders, and death. Left …

Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …