Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

Regeneration is the process of replacing/restoring a damaged cell/tissue/organ to its full
function and is limited respecting complexity of specific organ structures and the level of …

The imbalance between reactive oxygen species (ROS) production and clearance causes
oxidative stress and ROS, which play a central role in regulating cell and tissue physiology …

Chronic diseases represent a major challenge in world health. Metabolic syndrome is a
constellation of disturbances affecting several organs, and it has been proposed to be a liver …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Reactive oxygen species (ROS) are identified to control the expression and activity of
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

The NRF2–KEAP1 system is a fundamental component of the cellular response that controls
a great variety of transcriptional targets that are mainly involved in the regulation of redox …