Parasitic diseases remain a major public health problem affecting hundreds of millions of
people, particularly in tropical developing countries. The limited availability and affordability …

The aromatic β-carbolines norharman and harman have been implicated in a number of
human diseases including Parkinson's disease, tremor, addiction and cancer. It has been …

New drugs are urgently required for the treatment of amoebiasis, leishmaniasis, malaria and
trypanosomiasis. In this review the potential of natural plant products as a source of …

Publisher Summary This chapter provides evidence that alkaloids are not waste products or
functionless molecules as formerly assumed, but rather defense compounds employed by …

A prediction algorithm of the binding affinity of ligands to trypanothione reductase (TR), the
enzyme replacing glutathione reductase in the metabolism of trypanosomatidae, has been …

Emetine is a natural product alkaloid from ipecac species. It is one of the main active
ingredients in ipecac syrup used as emetic, and has been used extensively in …

The chemotherapy of Chagas' disease remains an unsolved problem, and the search for
alternative drugs continues. Only two nitroheterocyclic drugs are in clinical use at the …

Publisher Summary This chapter provides an update on pyridine and piperidine alkaloids.
Cardiovascular effects of nicotine and cotinine have been studied. One study reported an …

Borreira and Spermacoce are genera of Rubiaceae widespread in tropical and subtropical
America, Africa, Asia, and Europe. Based on its fruits morphology they are considered by …

MATERIALS AND METHODS Materials Rosemary leaves were collected in the Medicinal
Plant Garden of Fukuoka University in August, 1999, and air-dried. Diaion HP 20, a styrene …