[HTML][HTML] Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side

A Jacquens, EJ Needham, ER Zanier, V Degos… - International journal of …, 2022 - mdpi.com
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

[HTML][HTML] Cognitive health after menopause: does menopausal hormone therapy affect it?

P Stute, J Wienges, AS Koller, C Giese… - Best Practice & …, 2021 - Elsevier
Dementia is a pandemic chronic non-communicable disease. 10 in 100 women above age
65 will be diagnosed with dementia, primarily Alzheimer's disease (AD). Apart from age and …

[HTML][HTML] 17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic …

AR Mayer, AB Dodd, JG Rannou-Latella… - Critical Care, 2021 - Springer
Background Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic
shock (HS) represent leading causes of trauma-induced mortality, especially when co …

The role of inhaled estradiol and myrtenol, alone and in combination, in modulating behavioral and functional outcomes following traumatic experimental brain injury …

MA Rajizadeh, M Khaksari, MA Bejeshk… - Neurocritical Care, 2023 - Springer
Background Traumatic brain injury (TBI) is an important and growing cause of disability
worldwide, and its cognitive consequences may be particularly significant. This study …

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

AS Al‐Shami, AE Essawy… - Phytotherapy …, 2023 - Wiley Online Library
Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain
disorders that have common features including progressive degeneration of the structure …

[HTML][HTML] Exploring sex-related differences in microglia may be a game-changer in precision medicine

MA Lynch - Frontiers in aging neuroscience, 2022 - frontiersin.org
One area of microglial biology that has been relatively neglected until recently is sexual
dimorphism and this is in spite of the fact that sex is a risk factor in several diseases that are …

Temporal changes in the microglial proteome of male and female mice after a diffuse brain injury using label‐free quantitative proteomics

YV Doust, A Bindoff, OG Holloway, R Wilson, AE King… - Glia, 2023 - Wiley Online Library
Traumatic brain injury (TBI) triggers neuroinflammatory cascades mediated by microglia,
which promotes tissue repair in the short‐term. These cascades may exacerbate TBI …

Matrix Metalloproteinase-9 inhibitors as therapeutic drugs for traumatic brain injury

A Sunny, RR James, SR Menon, S Rayaroth… - Neurochemistry …, 2023 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality among
young adults and the elderly. In the United States, TBI is responsible for around 30 percent …

[HTML][HTML] Comparison of antioxidant capacity and network pharmacology of Phloretin and Phlorizin against neuroinflammation in traumatic brain injury

KK Ongay, D Granato, GE Barreto - Molecules, 2023 - mdpi.com
Neuroinflammation is a hallmark of traumatic brain injury (TBI)'s acute and chronic phases.
Despite the medical and scientific advances in recent years, there is still no effective …

[HTML][HTML] Mitochondria as the target for disease related hormonal dysregulation

GA Shaw - Brain, Behavior, & Immunity-Health, 2021 - Elsevier
Mitochondria play an important role in the synthesis of steroid hormones, including the sex
hormone estrogen. Sex-specific regulation of these hormones is important for phenotypic …