Secretory cargo is recognized, concentrated and trafficked from endoplasmic reticulum (ER)
exit sites (ERES) to the Golgi. Cargo export from the ER begins when a series of highly …

In eukaryotic cells, the endoplasmic reticulum (ER) is a major site of synthesis of both lipids
and proteins, many of which must be transported to other organelles. The COPII coat …

The ER (endoplasmic reticulum) in higher plants forms a pleomorphic web of membrane
tubules and small cisternae that pervade the cytoplasm, but in particular form a polygonal …

Background While age and the APOE ε4 allele are major risk factors for Alzheimer's disease
(AD), a small percentage of individuals with these risk factors exhibit AD resilience by living …

Protein export from the endoplasmic reticulum (ER) to the Golgi apparatus occurs at
specialized regions known as the ER exit sites (ERES). In Saccharomyces cerevisiae, ERES …

Co-assembly of the multilayered coat protein complex II (COPII) with the Sar1 GTPase at
subdomains of the endoplasmic reticulum (ER) enables secretory cargoes to be …

COPII-coated buds are formed at endoplasmic reticulum exit sites (ERES) to mediate ER-to-
Golgi transport. Sec16 is an essential factor in ERES formation, as well as in COPII …

Ancestral coatomer element 1 (ACE1) proteins assemble latticework coats for COPII vesicles
and the nuclear pore complex. The ACE1 protein Sec31 and Sec13 make a 2: 2 tetramer …

The export of newly synthesized proteins from the endoplasmic reticulum is fundamental to
the ongoing maintenance of cell and tissue structure and function. After co-translational …

The endoplasmic reticulum (ER) is a functionally and morphologically complex cellular
organelle largely responsible for a variety of crucial functions, including protein folding …