Proteins synthesized within the endoplasmic reticulum (ER) are transported to the Golgi via
coat protein complex II (COPII)-coated vesicles. The formation of COPII-coated vesicles is …

All eukaryotes possess a secretory pathway, and the major molecular players involved in
secretion are well conserved. However, the morphological manifestation of this pathway at …

Sec16 plays a key role in the formation of coat protein II vesicles, which mediate protein
transport from the endoplasmic reticulum (ER) to the Golgi apparatus. Mammals have two …

Protein export from the endoplasmic reticulum (ER), the first step in protein transport through
the secretory pathway, is mediated by coatomer protein II (COPII)-coated vesicles at ER exit …

COPII vesicles mediate the export of secretory cargo from endoplasmic reticulum (ER) exit
sites. However, of 60–90 nm diameter COPII vesicles are too small to accommodate …

Tumor Necrosis Factor receptor-associated factor-3 (TRAF3) is a central mediator important
for inducing type I interferon (IFN) production in response to intracellular double-stranded …

PARK20, an early onset autosomal recessive parkinsonism is due to mutations in the
phosphatidylinositol-phosphatase Synaptojanin 1 (Synj1). We have recently shown that the …

Accurate maintenance of organelle identity in the secretory pathway relies on retention and
retrieval of resident proteins. In the endoplasmic reticulum (ER), secretory proteins are …

Protein export from the endoplasmic reticulum (ER) is an initial and rate-limiting step of
molecular trafficking and secretion. This is mediated by coat protein II (COPII)-coated …

Obesity has become a public health problem worldwide. Compared with Europe, people in
Asia tend to suffer from type 2 diabetes with a lower body mass index (BMI). Genome-wide …