With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Female reproductive capacity declines dramatically in the fourth decade of life as a result of
an age‐related decrease in oocyte quality and quantity. The primary causes of reproductive …

Background Management of women with reduced ovarian reserve or poor ovarian response
(POR) to stimulation is one of the major challenges in reproductive medicine. The primary …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Objective To investigate the clinical relevance of mitochondrial DNA (mtDNA) content as a
viability score in human euploid embryos. Design Retrospective analysis of mtDNA content …

Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …