The use of mitochondrial transfer as a clinic procedure is drawing closer to reality. Here we
provide a detailed overview of mitochondrial transfer techniques–both established and …

In several species, oocyte and embryo competence are improved by the addition of
endoplasmic reticulum (ER) stress inhibitors to in vitro maturation (IVM) medium and/or in …

Mitochondrial dysfunction can cause female infertility. An important unresolved issue is the
extent to which incompatibility between mitochondrial and nuclear genomes contributes to …

Despite recent striking advances in assisted reproductive technology (ART), poor ovarian
response (POR) diagnosis and treatment is still considered challenging. Poor responders …

The one carbon metabolism (OCM) has a primary role in the process of oocyte maturation. In
this study bovine oocytes were cultured for 24 h, up to MII stage, with standard medium …

Background Female fertility declines with age, due to increased chromosomal aneuploidy
and possible reduced mitochondrial function in the embryo. Methods This review outlines …

Maternal aging has been reported to reduce oocyte quality and, in turn, lower the
developmental potential of the resulting embryos. Here, we show that maternally aged …

Oocyte health is tightly tied to mitochondria given their role in energy production, metabolite
supply, calcium (Ca 2+) buffering, and cell death regulation, among others. In turn …

Oogenesis is one of the first processes to fail during aging. In women, most oocytes cannot
successfully complete meiotic divisions already during the fourth decade of life. Studies of …

Early life exposure to adverse environments can lead to a variety of metabolic and
cardiovascular diseases in offspring. We hypothesize that female reproductive function may …