[HTML][HTML] Involvement of lipids in Alzheimer's disease pathology and potential therapies

H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Alzheimer disease in African American individuals: increased incidence or not enough data?

LL Barnes - Nature Reviews Neurology, 2022 - nature.com
Research on racial differences in Alzheimer disease (AD) dementia has increased in recent
years. Older African American individuals bear a disproportionate burden of AD and …

Factors associated with healthy aging in Latin American populations

H Santamaria-Garcia, A Sainz-Ballesteros… - Nature Medicine, 2023 - nature.com
Latin American populations may present patterns of sociodemographic, ethnic and cultural
diversity that can defy current universal models of healthy aging. The potential combination …

Validation of plasma amyloid-β 42/40 for detecting Alzheimer disease amyloid plaques

Y Li, SE Schindler, JG Bollinger, V Ovod… - Neurology, 2022 - AAN Enterprises
Background and Objectives To determine the diagnostic accuracy of a plasma Aβ42/Aβ40
assay in classifying amyloid PET status across global research studies using samples …

Disparities by race and ethnicity among adults recruited for a preclinical Alzheimer disease trial

R Raman, YT Quiroz, O Langford, J Choi… - JAMA Network …, 2021 - jamanetwork.com
Importance Underrepresentation of many racial/ethnic groups in Alzheimer disease (AD)
clinical trials limits generalizability of results and hinders opportunities to examine potential …

Early-stage Alzheimer disease: getting trial-ready

PS Aisen, GA Jimenez-Maggiora, MS Rafii… - Nature Reviews …, 2022 - nature.com
Slowing the progression of Alzheimer disease (AD) might be the greatest unmet medical
need of our time. Although one AD therapeutic has received a controversial accelerated …

Black and White individuals differ in dementia prevalence, risk factors, and symptomatic presentation

JC Lennon, SL Aita, VAD Bene, T Rhoads… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Although dementia prevalence differs by race, it remains unclear whether
cognition and neuropsychiatric symptom severity differ between Black and White individuals …

Improving representation in clinical trials and research: building research equity for women and underrepresented groups

K Bibbins-Domingo, A Helman - 2022 - pubmed.ncbi.nlm.nih.gov
The United States has long made substantial investments in clinical research with the goal
of improving the health and well-being of our nation. There is no doubt that these …

Association of neighborhood-level disadvantage with Alzheimer disease neuropathology

WR Powell, WR Buckingham, JL Larson… - JAMA network …, 2020 - jamanetwork.com
Importance Social determinants of health, such as income, education, housing quality, and
employment, are associated with disparities in Alzheimer disease and health generally, yet …

Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group

HN Yassine, C Samieri, G Livingston… - The Lancet Healthy …, 2022 - thelancet.com
Observational studies suggest that nutritional factors have a potential cognitive benefit.
However, systematic reviews of randomised trials of dietary and nutritional supplements …