Background: Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a
major cause of stroke. Unfortunately, current treatments of AF are suboptimal because they …

Aging comes with gradual loss of functions that increase the vulnerability to disease,
senescence, and death. The mechanisms underlying these processes are linked to a …

The present study was designed to investigate whether endogenous sulphur dioxide (SO2)
controlled pulmonary inflammation in a rat model of oleic acid (OA)-induced acute lung …

Background Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is a
potential cause of thromboembolic events. AF induces significant changes in the …

Rationale: Hydrogen peroxide (H2O2) regulates vascular tone in the human microcirculation
under physiological and pathophysiological conditions. It dilates arterioles by activating …

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …

Although the initiation, development, and maintenance of atrial fibrillation (AF) have been
linked to alterations in myocyte redox state, the field lacks a complete understanding of the …

In mammalian skeletal muscle, Ca 2+ release from the sarcoplasmic reticulum (SR) through
the ryanodine receptor/Ca 2+-release channel RyR1 can be enhanced by S-oxidation or S …

AMPK has been reported to facilitate hypoxic pulmonary vasoconstriction but, paradoxically,
its deficiency precipitates pulmonary hypertension. Here we show that AMPK-α1/α2 …

Reactive oxygen species (ROS) and especially hydrogen peroxide, are potent signaling
molecules that activate cellular defense responses. Hydrogen peroxide can provoke …