Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Context Presence of low-frequency, or minority, human immunodeficiency virus type 1 (HIV-
1) drug resistance mutations may adversely affect response to antiretroviral treatment (ART) …
1) drug resistance mutations may adversely affect response to antiretroviral treatment (ART) …
Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a …
L Wittkop, HF Günthard, F De Wolf, D Dunn… - The Lancet infectious …, 2011 - thelancet.com
Background The effect of transmitted drug resistance (TDR) on first-line combination
antiretroviral therapy (cART) for HIV-1 needs further study to inform choice of optimum drug …
antiretroviral therapy (cART) for HIV-1 needs further study to inform choice of optimum drug …
[HTML][HTML] Applications of next-generation sequencing technologies to diagnostic virology
Novel DNA sequencing techniques, referred to as “next-generation” sequencing (NGS),
provide high speed and throughput that can produce an enormous volume of sequences …
provide high speed and throughput that can produce an enormous volume of sequences …
Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a …
RL Hamers, R Schuurman, KCE Sigaloff… - The Lancet infectious …, 2012 - thelancet.com
Background The effect of pretreatment HIV-1 drug resistance on the response to first-line
combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed. We …
combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed. We …
Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and-adherent patients
KJ Metzner, SG Giulieri, SA Knoepfel… - Clinical infectious …, 2009 - academic.oup.com
Background. Early virological failure of antiretroviral therapy associated with the selection of
drug-resistant human immunodeficiency virus type 1 in treatment-naive patients is very …
drug-resistant human immunodeficiency virus type 1 in treatment-naive patients is very …
[PDF][PDF] European recommendations for the clinical use of HIV drug resistance testing: 2011 update
AM Vandamme, RJ Camacho, F Ceccherini-Silberstein… - Aids Rev, 2011 - academia.edu
Abstract The European HIV Drug Resistance Guidelines Panel, established to make
recommendations to clinicians and virologists, felt that sufficient new information has …
recommendations to clinicians and virologists, felt that sufficient new information has …
[HTML][HTML] Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naive subjects in the CASTLE study
M Lataillade, J Chiarella, R Yang, S Schnittman… - PloS one, 2010 - journals.plos.org
Background CASTLE compared the efficacy of atazanavir/ritonavir with lopinavir/ritonavir,
each in combination with tenofovir-emtricitabine in ARV-naïve subjects from 5 continents …
each in combination with tenofovir-emtricitabine in ARV-naïve subjects from 5 continents …
Low-abundance drug-resistant HIV-1 variants in antiretroviral drug-naive individuals: a systematic review of detection methods, prevalence, and clinical impact
Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …
Clinical management of HIV-1 resistance
Antiretroviral drug resistance is a fundamental survival strategy for the virus that stems from
its vast capacity to generate diversity. With the recent availability of new ARV drugs and …
its vast capacity to generate diversity. With the recent availability of new ARV drugs and …