Oxidative stress and hypertension
KK Griendling, LL Camargo, FJ Rios… - Circulation …, 2021 - Am Heart Assoc
A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …
animal models of hypertension but remains elusive in humans. While initial studies focused …
Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease
Q Yan, S Liu, Y Sun, C Chen, S Yang, M Lin… - Journal of Translational …, 2023 - Springer
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …
On the clinical pharmacology of reactive oxygen species
Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …
Dyslipidemia, diabetes and atherosclerosis: role of inflammation and ROS-redox-sensitive factors
E Hasheminasabgorji, JC Jha - Biomedicines, 2021 - mdpi.com
The prevalence of diabetes is growing at an alarming rate with increased disability,
morbidity, and often premature mortality because of the various complications of this …
morbidity, and often premature mortality because of the various complications of this …
Nrf2 as a potential mediator of cardiovascular risk in metabolic diseases
Free radicals act as secondary messengers, modulating a number of important biological
processes, including gene expression, ion mobilization in transport systems, protein …
processes, including gene expression, ion mobilization in transport systems, protein …
The homeostatic role of hydrogen peroxide, superoxide anion and nitric oxide in the vasculature
Reactive oxygen and nitrogen species are produced in a wide range of physiological
reactions that, at low concentrations, play essential roles in living organisms. There is a …
reactions that, at low concentrations, play essential roles in living organisms. There is a …
NADPH oxidases: from molecular mechanisms to current inhibitors
A Cipriano, M Viviano, A Feoli, C Milite… - Journal of medicinal …, 2023 - ACS Publications
NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …
[HTML][HTML] AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury
A Marino, DJ Hausenloy, I Andreadou… - Free Radical Biology …, 2021 - Elsevier
Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …
Endothelial and vascular smooth muscle dysfunction in hypertension
The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …
NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension
GA Knock - Free Radical Biology and Medicine, 2019 - Elsevier
The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …