Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐
inflammatory senescence‐associated secretory phenotype (SASP), which is a major …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone,
has beneficial effects on several body systems other than the musculoskeletal system. Both …

Neuroinflammation is one of the main mechanisms involved in the progression of several
neurodegenerative diseases, such as Parkinson, Alzheimer, multiple sclerosis, amyotrophic …

Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced
through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist …

Abstract Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and
hallmarks of aging are identified as key contributors to aging, but improving/reversing these …