Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …

According to Alzheimer's Disease International, 55 million people worldwide are living with
dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually …

The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed
different phenotypes that are inherently associated with disease conditions. A common …

Obesity has been associated with oxidative stress. Obese patients are at increased risk for
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …

Schisandra chinensis (S. chinensis) is an herbal medicine used for the treatment of
Alzheimer's disease (AD). The purified polysaccharide fraction, namely SCP2, was …

Biological aging can be described as accumulative, prolonged metabolic stress and is the
major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified …

Alzheimer's disease (AD) is a neurodegenerative disease with amyloid beta (Aβ) deposition
and intracellular neurofibrillary tangles (NFTs) as its characteristic pathological changes …

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

In mitotic cells, cellular senescence is a permanent state of G1 arrest, that may have evolved
in parallel to apoptosis, to limit proliferation of damaged cells and oncogenesis. Recent …