Alzheimer's disease (AD) is the most prevalent form of dementia, particularly in old age
subjects. Hyperinsulinemia and insulin resistance, which are known as pathophysiological …

Objective. Aging and AD are associated in some way, then it is reasonable to ask whether or
not it is possible to age without AD inexorably appearing at any moment, depending on the …

The brain is one of the most energy-consuming organs in the body. Satisfying such energy
demand requires compartmentalized, cell-specific metabolic processes, known to be …

Post-exertional malaise (PEM) is a hallmark symptom of myalgic encephalomyelitis/chronic
fatigue syndrome (ME/CFS). We monitored the evolution of 1157 plasma metabolites in 60 …

Background Metabolic dysfunction and neuroinflammation are increasingly implicated in
Parkinson's disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway …

Alzheimer's disease (AD) is characterized by amyloid (A) β peptide accumulation and
intracellular neurofibrillary tangles. New hypotheses have suggested that AD involves …

Oxidative damage, mitochondrial dysfunction, and neuroinflammation are strongly
implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's …

The first study documenting a decline in memory between the ages of 20 and 70 years was
conducted by Willoughby 1 in 1929. He did a digital substitution test and found that there …

Significance: Accumulating evidence suggests that inflammation is a major contributor in the
pathogenesis of several highly prevalent, but also rare, neurological diseases. In particular …

The concept of “aging” is defined as the set of gradual and progressive changes in an
organism that leads to an increased risk of weakness, disease, and death. This process may …