Diabetes and Alzheimer's disease are common chronic illnesses in the United States and
lack clearly demonstrated therapeutics. Mitochondria, the “powerhouse of the cell”, is …

Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …

Abstracts Alzheimer's disease (AD) is a complex neurodegenerative disease characterized
by cognitive and short-term memory impairments. The disease involves multiple …

Oxidative stress and neuroinflammation are the key and early events during the pathological
process of Parkinson's disease (PD). Thus, therapeutic intervention to regulate oxidative …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …

Research to date has provided novel insights into lactate's positive role in multiple brain
functions and several brain diseases. Although notable controversies and discrepancies …

People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Oligodendrocytes form the myelin that ensheaths CNS axons, which is essential for rapid
neuronal signalling and underpins the massive computing power of the human brain …

People with migraine are prone to a brain energy deficit between attacks, through increased
energy demand (hyperexcitable brain) or decreased supply (mitochondrial impairment) …

Cerebral energy metabolism in Alzheimer disease (AD) has recently been given increasing
attention. This study focuses on the alterations of cerebral lactate metabolism in the double …