Contraceptive devices: subcutaneous delivery systems
G Benagiano, H Gabelnick, M Farris - Expert review of medical …, 2008 - Taylor & Francis
Ever since natural sex hormones have been identified, their structure defined and their
synthesis achieved, it became clear that their circulating half-life was too short to allow use …
synthesis achieved, it became clear that their circulating half-life was too short to allow use …
Steroid release from silastic capsules and rods
HA Nash, DN Robertson, AJM Young, LE Atkinson - Contraception, 1978 - Elsevier
The release of steroids from Silastic R capsules and rods has been measured in human
beings and rats by recovering the implants after periods of subdermal implantation and …
beings and rats by recovering the implants after periods of subdermal implantation and …
Levonorgestrel and estradiol release from an improved contraceptive vaginal ring
TM Jackanicz - Contraception, 1981 - Elsevier
A contraceptive vaginal ring containing levonorgestrel and estradiol was designed in which
the drug is located in a 0.15-mm layer beneath a 0.25-mm overcoat at the ring's surface …
the drug is located in a 0.15-mm layer beneath a 0.25-mm overcoat at the ring's surface …
Contraception with long acting subdermal implants: I. An effective and acceptable modality in international clinical trials
E Coutinho, AR da Silva, CER Mattos, S Diaz… - Contraception, 1978 - Elsevier
This paper presents results of a double blind, multi-centered and multi-national study of two
progestin only subdermal implants used for contraception. A regimen of six capsules of …
progestin only subdermal implants used for contraception. A regimen of six capsules of …
In Vivo Metabolism of Progestins. V. The Effect of Protocol Design on the Estimated Metabolic Clearance Rate and Volume of Distribution of Medroxyprogesterone …
C GUPTA, J OSTERMAN, R SANTEN… - The Journal of Clinical …, 1979 - academic.oup.com
The metabolism of the synthetic progestin,[3H] medroxyprogesterone acetate (MPA), was
studied in women using a single injection technique. Computer-implemented analysis was …
studied in women using a single injection technique. Computer-implemented analysis was …
Spermatogenesis in men treated with subcutaneous application of levonorgestrel and estrone rods
J Frick, CH Danner, H Joos, G Kunit… - Journal of …, 1981 - Wiley Online Library
The effects of a combination of a progestin, levonorgestrel (LNg), and estrone (E1), on
exocrine and endocrine testicular function were examined in adult men. The mode of …
exocrine and endocrine testicular function were examined in adult men. The mode of …
The interaction between sex hormone binding globulin and levonorgestrel released from vaginal rings in women
SZ Cekan, M Jia, BM Landgren, E Diczfalusy - Contraception, 1985 - Elsevier
The levels of levonorgestrel (L-NOG), progesterone and estradiol were measured in plasma
samples of 17 normally menstruating women during a control cycle and during a …
samples of 17 normally menstruating women during a control cycle and during a …
Ectopic pregnancies associated with low dose progestagen-releasing IUDs
S Dfaz, HB Croxatto, M Pavez, E Quinteros, D Carrillo… - Contraception, 1980 - Elsevier
Dimethyl-polysiloxane capsules containing pure progestagens were attached to Tatum's T
IUDs and tested in 594 fertile women for contraceptive performance. The control group was …
IUDs and tested in 594 fertile women for contraceptive performance. The control group was …
Subdermal norethindrone pellets—a method for contraception?
V Odlind, AJ Moo-Young, GN Gupta, E Weiner… - Contraception, 1979 - Elsevier
The mode of action of compressed pellets containing 85 per cent norethindrone (NET) and
15 per cent cholesterol was studied. Four pellets were inserted subcutaneously, in each of …
15 per cent cholesterol was studied. Four pellets were inserted subcutaneously, in each of …
Suppression of reproductive function in autoimmune NZB/W mice: Effective doses of four contraceptive steroids
LW KEISLER, SE WALKER - American journal of reproductive …, 1987 - Wiley Online Library
Oral contraceptives have been implicated in causing flares of systemic lupus erythematosus
in humans, and studies of these agents in the NZB/W mouse model of lupus may help to …
in humans, and studies of these agents in the NZB/W mouse model of lupus may help to …