There is increasing evidence that mesenchymal stem cells (MSCs) have the ability to
migrate and engraft into tumor sites and exert stimulatory effects on cancer cell growth …

One of the important strategies for the treatment of cancer is gene therapy which has the
potential to exclusively eradicate malignant cells, without any damage to the normal tissues …

Pharmacokinetics, pharmacology, and toxicology are the major determinants of the success
or failure of candidates during drug development. Because inappropriate pharmacokinetics …

Gene therapy suggests a promising approach to treat genetic diseases by applying genes
as pharmaceuticals. Cancer is a complex disease, which strongly depends on a particular …

Gene-directed enzyme prodrug therapy (GDEPT) is a promising and emerging strategy that
attempts to limit the systemic toxicity inherent to cancer chemotherapy by means of tumor …

The approaches now united under the term “gene therapy” can be divided into two broad
strategies:(1) strategy using the ideology of molecular targeted therapy, but with genes in the …

Nanomedicines for controlled drug release provide temporal and spatial regulation of drug
bioavailability in the body. The timing of drug release is usually engineered either for slow …

Understanding and apprehension of the characteristics and circumstances in which
mesenchymal stem cells (MSCs) affect and make alterations (enhance or reduce) to the …

Escherichia coli nitroreductase (NTR) may convert the prodrug CB1954 (5-(aziridin-1-yl)-2, 4-
dinitrobenzamide) into a bifunctional alkylating agent, which may lead to DNA crosslinks …

This review discusses gene therapy as a new treatment paradigm where genetic material is
introduced into cells for therapeutic benefit. The genetic material is the 'drug'. It can have a …