A focus on secondary progressive multiple sclerosis (SPMS): challenges in diagnosis and definition

H Inojosa, U Proschmann, K Akgün, T Ziemssen - Journal of neurology, 2021 - Springer
Secondary progressive multiple sclerosis (SPMS) is the second most common form of
multiple sclerosis (MS). One in two relapse remitting multiple sclerosis (RRMS) patients will …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

Ponesimod compared with teriflunomide in patients with relapsing multiple sclerosis in the active-comparator phase 3 OPTIMUM study: a randomized clinical trial

L Kappos, RJ Fox, M Burcklen, MS Freedman… - JAMA …, 2021 - jamanetwork.com
Importance To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing
Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease …

[HTML][HTML] The therapeutic potential of non-invasive brain stimulation for the treatment of Long-COVID-related cognitive fatigue

S Linnhoff, L Koehler, A Haghikia, T Zaehle - Frontiers in immunology, 2023 - frontiersin.org
Following an acute COVID-19 infection, a large number of patients experience persisting
symptoms for more than four weeks, a condition now classified as Long-COVID syndrome …

[HTML][HTML] Fatigue in multiple sclerosis: a review of the exploratory and therapeutic potential of non-invasive brain stimulation

SS Ayache, N Serratrice, GN Abi Lahoud… - Frontiers in …, 2022 - frontiersin.org
Fatigue is the most commonly reported symptom in patients with multiple sclerosis (MS). It is
a worrisome, frequent, and debilitating manifestation that could occur at any time during the …

[HTML][HTML] Fatigue, depression, and anxiety among ambulating multiple sclerosis patients

S AlSaeed, T Aljouee, NM Alkhawajah… - Frontiers in …, 2022 - frontiersin.org
Background Multiple sclerosis (MS) is an inflammatory disease associated with adverse
effects: including depression, anxiety, fatigue, which may affect physical activity and the …

Temperature sensitivity in multiple sclerosis: an overview of its impact on sensory and cognitive symptoms

A Christogianni, R Bibb, SL Davis, O Jay, M Barnett… - Temperature, 2018 - Taylor & Francis
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by
demyelination of the central nervous system (CNS). The exact cause of MS is still unknown; …

[HTML][HTML] Cognitive fatigue in multiple sclerosis: an objective approach to diagnosis and treatment by transcranial electrical stimulation

S Linnhoff, M Fiene, HJ Heinze, T Zaehle - Brain Sciences, 2019 - mdpi.com
Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated
with significant impairment in daily functioning and quality of life. Despite its clinical …

Brain anatomical correlates of fatigue in multiple sclerosis

M Palotai, CRG Guttmann - Multiple Sclerosis Journal, 2020 - journals.sagepub.com
Fatigue is one of the most debilitating symptoms in patients with multiple sclerosis (MS).
Despite its clinical significance, the aetiology and pathophysiology of MS-related fatigue are …

Electrophysiological and behavioral effects of frontal transcranial direct current stimulation on cognitive fatigue in multiple sclerosis

M Fiene, KS Rufener, M Kuehne, M Matzke… - Journal of …, 2018 - Springer
Fatigue is one of the most common and debilitating symptoms affecting patients with multiple
sclerosis (MS). Sustained cognitive effort induces cognitive fatigue, operationalized as …