Pancreatic ductal adenocarcinoma (PDA) has become one of the leading causes of cancer-
related deaths across the world. A lack of durable responses to standard-of-care …

Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …

Chronic inflammation is a prerequisite for the development of cancers. Here, we present the
framework of a novel theory termed as Cancer Evolution-Development (Cancer Evo-Dev) …

Abstract Homeobox B9 (HOXB9) is involved in the occurrence and development of
malignant tumors. However, the functions and underlying molecular mechanisms of HOXB9 …

Simple Summary The large amount of knowledge regarding epigenetic pathways has
opened a broad range of treatments that provide hope for adult patients with highly …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Emerging evidence demonstrates that intratumor bacteria promote tumor resistance to
gemcitabine chemotherapy. The underlying mechanism is relate to intratumor bacteria …

Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene
encoding the pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among the top …

Simple Summary Epigenetic alterations contribute to the distinct biology of pancreatic ductal
adenocarcinoma (PDAC) and thus allow a better understanding of molecular mechanisms …

Background Active breast cancer-associated fibroblasts (CAFs) play a leading role in breast
carcinogenesis through promoting angiogenesis and resistance to therapy. Consequently …