Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Toxic effects of excessive manganese (Mn) from occupational or environmental exposure
cause harm to human health. Excessive Mn exposure is intimately associated with …

Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …

The Flaviviridae virus family members cause severe human diseases and are responsible
for considerable mortality and morbidity worldwide. Therefore, researchers have conducted …

The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome
remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify …

ABSTRACT TMEM120A (TACAN) is an enigmatic protein with several seemingly
unconnected functions. It was proposed to be an ion channel involved in sensing …

The nuclear factor κB (NF-κB) pathway plays essential roles in innate and adaptive
immunity, but little is known how NF-κB signaling is compartmentalized and spatiotemporally …

Stimulator of interferon genes (STING) is a crucial adaptor protein in the innate immune
response. STING activation triggers cytokine secretion, including type I interferon and …

Ion channels are the second largest class of drug targets after G protein-coupled receptors.
In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and …