Although chondrogenesis and osteogenesis are considered as two separate processes
during endochondral bone formation after birth, recent studies have demonstrated the direct …

Challenging skeletal repairs are frequently seen in patients experiencing systemic
inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we …

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are well-established as vital
regulators of fracture healing, whereas angiogenesis is one of the critical processes during …

Calvarial bones are connected by fibrous sutures. These sutures provide a niche
environment that includes mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts …

Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI),
frequently occur together. Clinical observation has long held that TBI can accelerate fracture …

In this study, we engineered mesenchymal stem cells (MSCs) to over-express basic
fibroblast growth factor (bFGF) and evaluated its effects on fracture healing. Adipose-derived …

Critical size bone defects represent a significant challenge worldwide, often leading to
persistent pain and physical disability that profoundly impact patients' quality of life and …

Organismal aging involves the progressive decline in organ function and increased
susceptibility to age-associated diseases. This has been associated with the aging of stem …

Bone fracture is a growing public health burden and there is a clinical need for non-invasive
therapies to aid in the fracture healing process. Previous studies have demonstrated the …

In this study, periodontal ligament (PDL) stem cells (PDLSCs) derived from different-aged
donors were used to evaluate the effect of aging on cell sheet formation. The activity of …