The beneficial or deleterious effects of nanomedicines emerge from their complex
interactions with intracellular pathways and their subcellular fate. Moreover, the dynamic …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-
renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling …

The MTT assay (to a less degree MTS, XTT or WST) is a widely exploited approach for
measuring cell viability/drug cytotoxicity. MTT reduction occurs throughout a cell and can be …

Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

The specificities of 28 commercially available compounds reported to be relatively selective
inhibitors of particular serine/threonine-specific protein kinases have been examined …

The specificities of 65 compounds reported to be relatively specific inhibitors of protein
kinases have been profiled against a panel of 70–80 protein kinases. On the basis of this …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a high-risk infectious
pathogen. In the proposed model of respiratory failure, SARS-CoV down-regulates its …

The plasma membrane represents an impermeable barrier for most macromolecules. Still
some proteins and so‐called cell‐penetrating peptides enter cells efficiently. It has been …

Herein we report a novel strategy for the design and construction of natural and natural
product-like libraries based on the principle of privileged structures, a term originally …