The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The transmembrane proteins of the tetraspanin superfamily are implicated in a diverse
range of biological phenomena, including cell motility, metastasis, cell proliferation and …

Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products:
carbon monoxide (CO), biliverdin, and ferrous iron. It participates in maintaining cellular …

Corticosteroid hormones play an important role in the control of vascular smooth muscle
tone by their permissive effects in potentiating vasoactive responses to catecholamines …

Caveolae are specialized membrane microdomains present within the plasma membrane of
the vast majority of cell types. They have a unique composition in that they are highly …

Recent biophysical data suggest that the properties of ceramide observed in model
membranes may apply to biological systems. In particular, the ability of ceramide to form …

Estrogen elicits a selective enhancement of the growth and differentiation of axons and
dendrites (neurites) in the developing brain. Widespread colocalization of estrogen and …

Caveolae are subcellular structures implicated in the import and transcytosis of
macromolecules and in transmembrane signaling. To date, evidence for the existence of …

Activation of a given type of G protein-coupled receptor (GPCR) triggers a limited set of
signalling events in a very rapid and specific manner. The classical paradigm of GPCR …

Until 1996, when estrogen receptor (ER)-β was discovered, life seemed simple. The
gonadal steroid hormone 17β-estradiol had one receptor, the ER, a ligand-inducible nuclear …