Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises
five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003 …

Introduction Immune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer
therapy as single agents or in combination regimens both in adults and children …

The induction of cuproptosis, a recently identified form of copper‐dependent immunogenic
cell death, is a promising approach for antitumor therapy. However, sufficient accumulation …

Mammalian members of the lysyl oxidase (LOX) family of proteins carry a copper-dependent
monoamine oxidase domain exclusively within the C-terminal region, which catalyzes ε …

Background Lipid droplet formation is a prominent histological feature in clear cell renal cell
carcinoma (ccRCC), but the significance and mechanisms underlying lipid droplet …

The etiology of osteonecrosis of the femoral head (ONFH) is not yet fully understood.
However, ONFH is a common disease with high morbidity, and approximately one-third of …

Background Metastasis is one of the leading cause contributes to treatment failure and poor
prognosis of hepatocellular carcinoma (HCC) patients. The underlying mechanism of HCC …

Pyroptosis, which is a novel form of immunogenic cell death, plays a vital role in antitumor
therapy. Zirconium-based metal–organic frameworks (Zr-MOFs) have been applied in …

Background Lung cancer is one of the malignant tumors with the highest morbidity and
fatality rates worldwide. The overall survival (OS) of lung adenocarcinoma (LUAD) is poor …

Excessive exposure to manganese in the environment or workplace is strongly linked to
neurodegeneration and cognitive impairment, but the precise pathogenic mechanism and …