Stromal cell–derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of …

JD Abbott, Y Huang, D Liu, R Hickey, DS Krause… - Circulation, 2004 - Am Heart Assoc
Background—After myocardial infarction (MI), bone marrow–derived cells (BMDCs) are
found within the myocardium. The mechanisms determining BMDC recruitment to the heart …

The SDF-1–CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis

I Petit, D Jin, S Rafii - Trends in immunology, 2007 - cell.com
Pro-angiogenic bone marrow (BM) cells include subsets of hematopoietic cells that provide
vascular support and endothelial progenitor cells (EPCs), which under certain permissive …

Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF‐1–CXCR4 axis

M Kucia, R Reca, K Miekus, J Wanzeck… - Stem …, 2005 - academic.oup.com
The α‐chemokine stromal‐derived factor (SDF)‐1 and the G‐protein–coupled seven‐span
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …

A population of very small embryonic-like (VSEL) CXCR4+ SSEA-1+ Oct-4+ stem cells identified in adult bone marrow

M Kucia, R Reca, FR Campbell, E Zuba-Surma… - Leukemia, 2006 - nature.com
By employing multiparameter sorting, we identified in murine bone marrow (BM) a
homogenous population of rare (∼ 0.02% of BMMNC) Sca-1+ lin− CD45− cells that express …

Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal‐derived factor‐1‐CXCR4 and hepatocyte growth factor‐c‐met axes …

BR Son, LA Marquez‐Curtis, M Kucia… - Stem …, 2006 - academic.oup.com
Human mesenchymal stem cells (MSCs) are increasingly being considered in cell‐based
therapeutic strategies for regeneration of various organs/tissues. However, the signals …

Invasive growth: a MET-driven genetic programme for cancer and stem cells

C Boccaccio, PM Comoglio - Nature Reviews Cancer, 2006 - nature.com
Metastasis follows the inappropriate activation of a genetic programme termed invasive
growth, which is a physiological process that occurs during embryonic development and …

[PDF][PDF] Transplantation of bone marrow cells reduces CCl4‐induced liver fibrosis in mice

I Sakaida, S Terai, N Yamamoto, K Aoyama… - …, 2004 - Wiley Online Library
We investigated the effect of bone marrow cell (BMC) transplantation on established liver
fibrosis. BMCs of green fluorescent protein (GFP) mice were transplanted into 4‐week …

The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer

J Wang, Y Shiozawa, J Wang, Y Wang, Y Jung… - Journal of Biological …, 2008 - ASBMB
Several reports have recently documented that CXCR7/RDC1 functions as a chemokine
receptor for SDF-1/CXCL12, which regulates a spectrum of normal and pathological …

Vascular repair by endothelial progenitor cells

A Zampetaki, JP Kirton, Q Xu - Cardiovascular research, 2008 - academic.oup.com
Accumulating evidence indicates the impact of endothelial progenitor cells (EPCs) in
vascular repair. In patients, the number of EPCs is negatively correlated with the severity of …

SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells

E De Falco, D Porcelli, AR Torella, S Straino… - Blood, 2004 - ashpublications.org
Chemokine stromal derived factor 1 (SDF-1) is involved in trafficking of hematopoietic stem
cells (HSCs) from the bone marrow (BM) to peripheral blood (PB) and has been found to …