Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Episodic memory deficits are consistently documented as a core aspect of cognitive
dysfunction in schizophrenia patients, present from the onset of the illness and strongly …

Classic cognitive theory conceptualizes executive functions as involving multiple specific
domains, including initiation, inhibition, working memory, flexibility, planning, and vigilance …

The challenge in understanding cognitive impairment in schizophrenia is that people with
this illness have deficits in an array of domains. Here, we briefly review evidence regarding …

Schizophrenia is frequently characterized as a disorder of brain connectivity. Neuroimaging
has played a central role in supporting this view, with nearly two decades of research …

Brain graphs provide a relatively simple and increasingly popular way of modeling the
human brain connectome, using graph theory to abstractly define a nervous system as a set …

Context Prefrontal cortical dysfunction is frequently reported in schizophrenia. It remains
unclear whether this represents the coincidence of several prefrontal region-and process …

The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are
related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of …

A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …