This Timeline article charts progress in mathematical modelling of cancer over the past 50
years, highlighting the different theoretical approaches that have been used to dissect the …

Cancer is a complex, multiscale process in which genetic mutations occurring at a
subcellular level manifest themselves as functional changes at the cellular and tissue scale …

Background The cause of preeclampsia remains unclear. Limited data suggest that excess
circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor …

Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-
1 (sFlt-1) is an antiangiogenic protein believed to mediate the signs and symptoms of …

Background—Targeted therapies to stabilize the clinical manifestations and prolong
pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an …

Karumanchi Angiogenic Factors and Preeclampsia 1073 to as fenestrations. Although it was
previously known that VEGF induces endothelial fenestrae in culture, 38 experimental data …

The aim of this study was to engineer a biomaterial capable of supporting vascularization in
vitro and in vivo. We covalently immobilized vascular endothelial growth factor (VEGF) and …

Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …

Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …

The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-
specific matrix, and high TNC expression is linked to poor prognosis in several cancers. To …