Mathematical model predicts effective strategies to inhibit VEGF-eNOS signaling
The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …
Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
A two-compartment model of VEGF distribution in the mouse
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …
new microvessels from existing microvasculature. Angiogenesis is a complex process …
Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells
S Sarabipour, K Kinghorn, KM Quigley… - PLoS computational …, 2024 - journals.plos.org
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
[HTML][HTML] Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization
Purpose To assess the effects of polysaccharide extract from Spirulina platensis (PSP) on
corneal neovascularization (CNV) in vivo and in vitro. Methods PSP was extracted from dry …
corneal neovascularization (CNV) in vivo and in vitro. Methods PSP was extracted from dry …
Fit-for-purpose biomarker method validation in anticancer drug development
J Cummings, TH Ward, C Dive - Drug discovery today, 2010 - Elsevier
The introduction of new anticancer drugs into the clinic is often hampered by a lack of
qualified biomarkers. Method validation is indispensable to successful biomarker …
qualified biomarkers. Method validation is indispensable to successful biomarker …
Immune cells regulate VEGF signalling via release of VEGF and antagonistic soluble VEGF receptor-1
T Hoeres, M Wilhelm, M Smetak… - Clinical & …, 2018 - academic.oup.com
Vascular endothelial growth factor (VEGF) is an important regulator of physiological and
pathological angiogenesis. Besides malignant and stromal cells, local immune cells shape …
pathological angiogenesis. Besides malignant and stromal cells, local immune cells shape …
VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model
FTH Wu, MO Stefanini, FM Gabhann… - American Journal …, 2010 - journals.physiology.org
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, the growth of
new capillaries from existing microvasculature. In peripheral arterial disease (PAD), lower …
new capillaries from existing microvasculature. In peripheral arterial disease (PAD), lower …
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …