Mathematical model predicts effective strategies to inhibit VEGF-eNOS signaling

Q Wu, SD Finley - Journal of Clinical Medicine, 2020 - mdpi.com
The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …

Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice

SD Finley, M Dhar, AS Popel - Frontiers in oncology, 2013 - frontiersin.org
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …

The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling

MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …

A two-compartment model of VEGF distribution in the mouse

P Yen, SD Finley, MO Engel-Stefanini, AS Popel - PloS one, 2011 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells

S Sarabipour, K Kinghorn, KM Quigley… - PLoS computational …, 2024 - journals.plos.org
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …

[HTML][HTML] Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization

L Yang, Y Wang, Q Zhou, P Chen, Y Wang… - Molecular …, 2009 - ncbi.nlm.nih.gov
Purpose To assess the effects of polysaccharide extract from Spirulina platensis (PSP) on
corneal neovascularization (CNV) in vivo and in vitro. Methods PSP was extracted from dry …

Fit-for-purpose biomarker method validation in anticancer drug development

J Cummings, TH Ward, C Dive - Drug discovery today, 2010 - Elsevier
The introduction of new anticancer drugs into the clinic is often hampered by a lack of
qualified biomarkers. Method validation is indispensable to successful biomarker …

Immune cells regulate VEGF signalling via release of VEGF and antagonistic soluble VEGF receptor-1

T Hoeres, M Wilhelm, M Smetak… - Clinical & …, 2018 - academic.oup.com
Vascular endothelial growth factor (VEGF) is an important regulator of physiological and
pathological angiogenesis. Besides malignant and stromal cells, local immune cells shape …

VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

FTH Wu, MO Stefanini, FM Gabhann… - American Journal …, 2010 - journals.physiology.org
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, the growth of
new capillaries from existing microvasculature. In peripheral arterial disease (PAD), lower …

A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands

LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …