The four variables, hypoxia, acidity, high glutathione (GSH) concentration and fast reducing
rate (redox) are distinct and varied characteristics of solid tumors compared to normal tissue …

Cancer is a persistent global health challenge, demanding continuous exploration of
innovative therapeutic strategies. Hydroxytyrosol (HT), derived from olive oil, has garnered …

A computational model is potentially a powerful tool to apprehend complex phenomena like
solid tumour growth and to predict the outcome of therapies. To that end, the confrontation of …

The binding of vascular endothelial growth factor (VEGF) superfamily to VEGF receptor
tyrosine kinases (VEGFRs) and co-receptors regulates vasculogenesis, angiogenesis and …

Over-expression of vascular endothelial growth factor A (VEGF-A) is correlated with
leukemia metastasis. VEGF-A acts by binding to its membrane receptors R1 and R2 present …

Tumour angiogenesis allows a growing mass of cancer cells to overcome oxygen diffusion
limitation and to increase cell survival. The growth of capillaries from pre-existing blood …

Neuroblastoma (NB) is a common pediatric malignancy characterized by clinical and
biological heterogeneity. A host of prognostic markers are available, contributing to accurate …

Rationale: We recently reported that ramipril more than doubled maximum walking times in
patients with peripheral artery disease with intermittent claudication. Objective: Our aim was …

Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …

Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the
ability to sense proteins in their environments. Many RTKs are essential to development and …