Systems biology will direct vascular-targeted therapy for obesity

Y Fang, T Kaszuba, PI Imoukhuede - Frontiers in Physiology, 2020 - frontiersin.org
Healthy adipose tissue expansion and metabolism during weight gain require coordinated
angiogenesis and lymphangiogenesis. These vascular growth processes rely on the …

Stimulus–responsive ultrasound contrast agents for clinical imaging: Motivations, demonstrations, and future directions

AP Goodwin, MA Nakatsuka… - Wiley Interdisciplinary …, 2015 - Wiley Online Library
Microbubble ultrasound contrast agents allow imaging of the vasculature with excellent
resolution and signal‐to‐noise ratios. Contrast in microbubbles derives from their interaction …

Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs

K Brookes, J Cummings, A Backen, A Greystoke… - British journal of …, 2010 - nature.com
Background: Successful introduction of new anticancer agents into the clinic is often
hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs …

Modeling of growth factor-receptor systems: from molecular-level protein interaction networks to whole-body compartment models

FTH Wu, MO Stefanini, F Mac Gabhann… - Methods in enzymology, 2009 - Elsevier
Most physiological processes are subjected to molecular regulation by growth factors, which
are secreted proteins that activate chemical signal transduction pathways through binding of …

[引用][C] 间充质干细胞分化的调控机制及其影响因素*★

华艳龙, 李彩萍 - Journal of Clinical Rehabilitative Tissue Engineering …, 2010

Inefficiency in macromolecular transport of SCS‐based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells

C Sanz‐Nogués, J Horan, K Thompson… - … Research Part A, 2015 - Wiley Online Library
Microcapsules made of sodium cellulose sulphate (SCS) and poly‐diallyl‐dimethyl‐
ammonium chloride (pDADMAC) have been employed to encapsulate a wide range of …

Soluble fms-like tyrosine kinase-1 antibody for diagnosis purposes (WO2010075475)

F Boyaud, N Inguimbert - Expert Opinion on Therapeutic Patents, 2011 - Taylor & Francis
Background: The application (WO2010075475) is involved in the diagnosis of angiogenesis-
dependent diseases related with the soluble FMS-like tyrosine kinase-1 (sFlt-1) biomarker …

Vesicle Trafficking and Secretion Regulate FLT1 Function in VEGF Signaling During Vascular Development

KA Kinghorn - 2023 - search.proquest.com
Blood vessels are essential for the delivery of oxygen and nutrients to every tissue within the
body, and proper vessel development is controlled by a balance in signaling regulators …

Neurotrophic Therapy for ALS/MND

M Dubowsky, SR Shepheard, ML Rogers - Handbook of Neurotoxicity, 2021 - Springer
Neurotrophic factors have a large range of activities in the nervous system that consist of
functions in development, plasticity, neurogenesis, disease, and injury. In the context of …

In silico modeling of angiogenesis at multiple scales: From nanoscale to organ system

AA Qutub, F Mac Gabhann… - … modeling of particle …, 2010 - books.google.com
Angiogenesis research has already led to therapies for cancer, anemia, macular
degeneration, and ischemia. In the coming decade, half a billion people worldwide are …