High fat diets (HFD) have been utilized in rodent models of visual disease for over 50 years
to model the effects of lipids, metabolic dysfunction, and diet-induced obesity on vision and …

Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct
balance between protein synthesis, folding and degradation. Proteostasis is essential for …

Background. Chronic hyperglycemia in type 1 diabetes (T1D) patients results in ocular
problems over time, but only a few studies emphasized on cataracts. Aim. To evaluate the …

To explore the pathogenesis of high myopia (HM) using quantitative proteomics. The
aqueous humor of patients with simple nuclear cataract and nuclear cataract complicated …

Background Cataract is one of the most common eye diseases that can further cause
blindness. Discovering susceptibility factors contributing to cataract development is helpful …

Diabetes is a major risk factor for cataract, the leading cause of blindness worldwide. There
is an unmet need for a realistic model of diabetic cataract for mechanistic and longitudinal …

Purpose To determine global protein expression changes in the lens of the GSH-deficient
LEGSKO mouse model of age-related cataract for comparison with recently published gene …

Oxidative stress is believed to be associated with both postmenopausal disorders and
cataract development. Previously, we have demonstrated that rosmarinic and sinapic acids …

Oxidative stress arises during numerous diseases, such as diabetes. It affects various
tissues and organs, including the eye lens leading eventually to cataract. Phenolic acids are …

Proteins in the aqueous humor (AH) are important in the induction of cataract development.
The identification of cataract-associated proteins assists in identifying patients and …