Observations about the number, frequency, effect size, and genomic distribution of alleles
associated with complex traits must be interpreted in light of evolutionary process. These …

Population geneticists have long sought to understand the contribution of natural selection
to molecular evolution. A variety of approaches have been proposed that use population …

The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …

Neutral theory predicts that genetic diversity increases with population size, yet observed
levels of diversity across metazoans vary only two orders of magnitude while population …

Insecticide resistance and rapid pest evolution threatens food security and the development
of sustainable agricultural practices, yet the evolutionary mechanisms that allow pests to …

The distribution of fitness effects (DFE) has considerable importance in population genetics.
To date, estimates of the DFE come from studies using a small number of individuals. Thus …

Limitation for amino acids is thought to regulate translation in mammalian cells primarily by
signaling through the kinases mTORC1 and GCN2. We find that a selective loss of arginine …

In this perspective, we evaluate the explanatory power of the neutral theory of molecular
evolution, 50 years after its introduction by Kimura. We argue that the neutral theory was …

A central question in evolutionary biology is why some species have more genetic diversity
than others and a no less important question is why selection efficacy varies among species …

As both natural selection and population history can affect genome-wide patterns of
variation, disentangling the contributions of each has remained as a major challenge in …